In the first corner, we have Jeff and Annie. They have been flirting all year long. They kissed in last season’s season finale. But is cynical Jeff really the type of guy who would settle down with cute ol’ naive little Annie? Does that make them the perfect couple? The irony and the fact that they are two completely different personalities?

In the second corner, we have House and Cuddy. House is an egotistic, self-loathing (GASP!), realistic, do good for nobody genius of a doctor. And he knows it. Cuddy is intelligent, beautiful, The Dean of Medicine and is House’s sexy boss. Sparks Fly. Drama happens. We love to watch.

So who should be crowned Top Couple of 2011? Head on over to E! Online to find out and to cast your vote. There’s still time people!